Structure of PDB 1lbc Chain A

Receptor sequence
>1lbcA (length=259) Species: 10116 (Rattus norvegicus) [Search protein sequence]
NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYK
LTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDF
SKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKI
AVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQ
RKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLSEQGLLDKLKN
KWWYDKGEC
3D structure
PDB1lbc Mechanism of glutamate receptor desensitization.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A E42 H46 E40 H44
BS02 GLU A Y61 L90 T91 R96 G141 S142 T143 E193 Y59 L88 T89 R94 G139 S140 T141 E191
BS03 CYZ A K104 P105 M107 S108 L239 S242 L247 D248 K102 P103 M105 S106 L237 S240 L245 D246 BindingDB: EC50=7600nM
BS04 CYZ A I92 S217 K218 G219 I90 S215 K216 G217 BindingDB: EC50=7600nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1lbc, PDBe:1lbc, PDBj:1lbc
PDBsum1lbc
PubMed12015593
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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