Structure of PDB 1lb5 Chain A

Receptor sequence
>1lb5A (length=155) Species: 9606 (Homo sapiens) [Search protein sequence]
QQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQ
LPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNH
EEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQRTFIKDDTLLVR
CEVST
3D structure
PDB1lb5 Distinct molecular mechanism for initiating TRAF6 signalling.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R392 F410 M450 A458 P468 K469 G470 F471 G472 Y473 R46 F64 M104 A112 P122 K123 G124 F125 G126 Y127
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0016567 protein ubiquitination
GO:0043122 regulation of canonical NF-kappaB signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1lb5, PDBe:1lb5, PDBj:1lb5
PDBsum1lb5
PubMed12140561
UniProtQ9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Gene Name=TRAF6)

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