Structure of PDB 1l9n Chain A

Receptor sequence
>1l9nA (length=673) Species: 9606 (Homo sapiens) [Search protein sequence]
AALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGSN
ERLEFIVSTGPYPSESAMTKAVFPLSNGSSGGWSAVLQASNGNTLTISIS
SPASAPIGRYTMALQIFSQGGISSVKLGTFILLFNPWLNVDSVFMGNHAE
REEYVQEDAGIIFVGSTNRIGMIGWNFGQFEEDILSICLSILDRSLNFRR
DAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNWSGTYTGGRDPRSWD
GSVEILKNWKKSGLSPVRYGQCWVFAGTLNTALRSLGIPSRVITNFNSAH
DTDRNLSVDVYYDPMGNPLDKGSDSVWNFHVWNEGWFVRSDLGPSYGGWQ
VLDATPQERSQGVFQCGPASVIGVREGDVQLNFDMPFIFAEVNADRITWL
YDNTTGKQWKNSVNSHTIGRYISTKAVGSNARMDVTDKYKYPEGSDQERQ
VFQKALGKLKPSIIGKLKVAGMLAVGKEVNLVLLLKNLSRDTKTVTVNMT
AWTIIYNGTLVHEVWKDSATMSLDPEEEAEHPIKISYAQYERYLKSDNMI
RITAVCKVPDESEVVVERDIILDNPTLTLEVLNEARVRKPVNVQMLFSNP
LDEPVRDCVLMVEGSGLLLGNLKIDVPTLGPKERSRVRFDILPSRSGTKQ
LLADFSCNKFPAIKAMLSIDVAE
3D structure
PDB1l9n Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions changes structure for activation.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) W236 C272 H330 D353 Y525
Catalytic site (residue number reindexed from 1) W236 C272 H330 D353 Y506
Enzyme Commision number 2.3.2.13: protein-glutamine gamma-glutamyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A N393 S415 H416 E443 E448 N393 S415 H416 E443 E448
BS02 CA A A221 N224 N226 D228 A221 N224 N226 D228
BS03 CA A D301 D303 N305 S307 D324 D301 D303 N305 S307 D324
Gene Ontology
Molecular Function
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0003824 catalytic activity
GO:0005198 structural molecule activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016746 acyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0018149 peptide cross-linking
GO:0030216 keratinocyte differentiation
GO:0031069 hair follicle morphogenesis
GO:0031424 keratinization
GO:0036211 protein modification process
Cellular Component
GO:0005737 cytoplasm
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032991 protein-containing complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1l9n, PDBe:1l9n, PDBj:1l9n
PDBsum1l9n
PubMed11980702
UniProtQ08188|TGM3_HUMAN Protein-glutamine gamma-glutamyltransferase E (Gene Name=TGM3)

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