Structure of PDB 1l8c Chain A

Receptor sequence
>1l8cA (length=95) Species: 10090 (Mus musculus) [Search protein sequence]
ADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHM
THCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKR
3D structure
PDB1l8c Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response.
ChainA
ResolutionN/A
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H18 C22 C35 C40 H18 C22 C35 C40
BS02 ZN A H49 C53 C59 C64 H49 C53 C59 C64
BS03 ZN A H73 C77 C82 C85 H73 C77 C82 C85
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1l8c, PDBe:1l8c, PDBj:1l8c
PDBsum1l8c
PubMed11959977
UniProtP45481|CBP_MOUSE Histone lysine acetyltransferase CREBBP (Gene Name=Crebbp)

[Back to BioLiP]