Structure of PDB 1l8b Chain A

Receptor sequence
>1l8bA (length=177) Species: 10090 (Mus musculus) [Search protein sequence]
KHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNL
MPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLL
CLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIGRVYKE
RLGLPPKIVIGYQSHADTATKKNRFVV
3D structure
PDB1l8b Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MGP A W56 M101 W102 E103 R157 K162 K206 W21 M66 W67 E68 R122 K127 K171 MOAD: Kd=0.14uM
BindingDB: Kd=10nM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
Biological Process
GO:0006413 translational initiation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1l8b, PDBe:1l8b, PDBj:1l8b
PDBsum1l8b
PubMed12054859
UniProtP63073|IF4E_MOUSE Eukaryotic translation initiation factor 4E (Gene Name=Eif4e)

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