Structure of PDB 1l7e Chain A

Receptor sequence
>1l7eA (length=372) Species: 1085 (Rhodospirillum rubrum) [Search protein sequence]
MKIAIPKERRPGEDRVAISPEVVKKLVGLGFEVIVEQGAGVGASITDDAL
TAAGATIASTAAQALSQADVVWKVQRPMTAEEGTDEVALIKEGAVLMCHL
GALTNRPVVEALTKRKITAYAMELMPRISRAQSMDILSSQSNLAGYRAVI
DGAYEFARAFPMMMTAAGTVPPARVLVFGVGVAGLQAIATAKRLGAVVMA
TDVRAATKEQVESLGGKFITVDDETAGGYAKEMGEEFRKKQAEAVLKELV
KTDIAITTALIPGKPAPVLITEEMVTKMKPGSVIIDLAVEAGGNCPLSEP
GKIVVKHGVKIVGHTNVPSRVAADASPLFAKNLLNFLTPHVDKDTKTLVM
KLEDETVSGTCVTRDGAIVHPA
3D structure
PDB1l7e Crystal Structures of Transhydrogenase Domain I with and without Bound NADH
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R127 Q132 D135 S138 Y235 E296
Catalytic site (residue number reindexed from 1) R127 Q132 D135 S138 Y229 E290
Enzyme Commision number 7.1.1.1: proton-translocating NAD(P)(+) transhydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI A R127 I128 Q132 D135 S138 G181 D202 V203 R204 A236 Q247 A265 L266 P273 L275 R127 I128 Q132 D135 S138 G181 D202 V203 R204 A230 Q241 A259 L260 P267 L269
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003957 NAD(P)+ transhydrogenase (Si-specific) activity
GO:0005515 protein binding
GO:0008750 proton-translocating NAD(P)+ transhydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046983 protein dimerization activity
GO:0050661 NADP binding
GO:0051287 NAD binding
GO:0070403 NAD+ binding
GO:0070404 NADH binding
Biological Process
GO:0006740 NADPH regeneration
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane

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Cellular Component
External links
PDB RCSB:1l7e, PDBe:1l7e, PDBj:1l7e
PDBsum1l7e
PubMed12379117
UniProtQ2RSB2|PNTAA_RHORT NAD(P) transhydrogenase subunit alpha part 1 (Gene Name=pntAA)

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