Structure of PDB 1l3w Chain A

Receptor sequence

>1l3wA (length=540) Species: 8355 (Xenopus laevis) [Search protein sequence]

DWVIPPIKVSENERGPFPKRLVQIKSNKDRFNKVYYSITGQGADNPPQGV
FRIEWETGWMLVTRPLDREEYDKYVLSSHAVSENGSPVEEPMEITINVID
QNDNRPKFTQDVFRGSVREGVQPGTQVMAVSATDEDDNIDSLNGVLSYSI
LKQDPEEPIPNLFTINRETGVISLIGTGLDREKFPEYTLTVQATDLEGAG
LSVEGKAIIQITDANDNAPIFDPKTYTALVPENEIGFEVQRLSVTDLDMP
GTPAWQAVYKIRVNEGGFFNITTDPESNQGILTTAKGLDFELRKQYVLQI
TVENAEPFSVPLPTSTATVTVTVEDVNEAPFFVPAVSRVDVSEDLSRGEK
IISLVAQDPDKQQIQKLSYFIGNDPARWLTVNKDNGIVTGNGNLDRESEY
VKNNTYTVIMLVTDDGVSVGTGTGTLILHVLDVNDNGPVPSPRVFTMCDQ
NPEPQVLTISDADIPPNTYPYKVSLSHGSDLTWKAELDSKGTSMLLSPTQ
QLKKGDYSIYVLLSDAQNNPQLTVVNATVCSCEGKAIKCQ

3D structure

PDB

1l3w C-cadherin ectodomain structure and implications for cell adhesion mechanisms

Chain

Resolution

3.08 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	A	N102 N104 D134 D136 N143 D195	N102 N104 D134 D136 N143 D195
BS02	CA	A	E11 R68 E69 D100 Q101 D103 D136	E11 R68 E69 D100 Q101 D103 D136
BS03	CA	A	E11 N12 D67 E69 D103	E11 N12 D67 E69 D103
BS04	CA	A	E119 E182 D213 A214 D216 D248	E119 E182 D213 A214 D216 D248
BS05	CA	A	E119 D180 E182 D216	E119 D180 E182 D216
BS06	CA	A	N215 N217 D246 D248 A254 N304	N215 N217 D246 D248 A254 N304
BS07	CA	A	E232 D289 F290 E291 E328	E232 D289 F290 E291 E328
BS08	CA	A	N327 E328 D358 D360 Q365 D414	N327 E328 D358 D360 Q365 D414
BS09	CA	A	E343 D395 E397 D435	E343 D395 E397 D435
BS10	CA	A	N434 N436 D461 D463 N467 D515	N434 N436 D461 D463 N467 D515
BS11	CA	A	E232 E291 D325 V326 E328 D360	E232 E291 D325 V326 E328 D360
BS12	CA	A	E343 E397 D432 V433 D435	E343 E397 D432 V433 D435

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609	cell-cell adhesion

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:1l3w, PDBe:1l3w, PDBj:1l3w
PDBsum	1l3w
PubMed	11964443
UniProt	P33148\|CADHF_XENLA EP-cadherin

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