Structure of PDB 1l1e Chain A

Receptor sequence
>1l1eA (length=272) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
YDLSDDFFRLFLDPTQTYSCAYFERDDMTLQEAQIAKIDLALGKLNLEPG
MTLLDIGCGWGATMRRAIEKYDVNVVGLTLSENQAGHVQKMFDQMDTPRS
RRVLLEGWEKFDEPVDRIVSIGAFEHFGHQRYHHFFEVTHRTLPADGKML
LHTIVRPTFKEGREKGLTLTHELVHFTKFILAEIFPGGWLPSIPTVHEYA
EKVGFRVTAVQSLQLHYARTLDMWATALEANKDQAIAIQSQTVYDRYMKY
LTGCAKLFRQGYTDVDQFTLEK
3D structure
PDB1l1e Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.79: cyclopropane-fatty-acyl-phospholipid synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO3 A S34 C35 E140 H167 S19 C20 E125 H152
BS02 SAH A T32 Y33 S34 G72 G74 L95 Q99 G122 W123 I136 F142 T17 Y18 S19 G57 G59 L80 Q84 G107 W108 I121 F127
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008610 lipid biosynthetic process
GO:0032259 methylation
GO:0042783 evasion of host immune response
GO:0046500 S-adenosylmethionine metabolic process
GO:0052167 symbiont-mediated perturbation of host innate immune response
GO:0071768 mycolic acid biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1l1e, PDBe:1l1e, PDBj:1l1e
PDBsum1l1e
PubMed11756461
UniProtP9WPB3|CMAS3_MYCTU Cyclopropane mycolic acid synthase 3 (Gene Name=pcaA)

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