Structure of PDB 1kzh Chain A

Receptor sequence
>1kzhA (length=550) Species: 139 (Borreliella burgdorferi) [Search protein sequence]
SLFKQERQKYIPKLPNILKKDFNNISLVYGENTEAIQDRQALKEFFKNTY
GLPIISFTEGESSLSFSKALNIGIILSGGPAPGGHNVISGVFDAIKKFNP
NSKLFGFKGGPLGLLENDKIELTESLINSYRNTGGFDIVSSGRTKIETEE
HYNKALFVAKENNLNAIIIIGGDDSNTNAAILAEYFKKNGENIQVIGVPK
TIDADLRNDHIEISFGFDSATKIYSELIGNLCRDAMSTKKYWHFVKLMGR
SASHVALECALKTHPNICIVSEEVLAKKKTLSEIIDEMVSVILKRSLNGD
NFGVVIVPEGLIEFIPEVKSLMLELCDIFDKNEGEFKGLNIEKMKEIFVA
KLSDYMKGVYLSLPLFIQFELIKSILERDPHGNFNVSRVPTEKLFIEMIQ
SRLNDMKKRGEYKGSFTPVDHFFGYEGRSAFPSNFDSDYCYSLGYNAVVL
ILNGLTGYMSCIKNLNLKPTDWIAGGVPLTMLMNMEERYGEKKPVIKKAL
VDLEGRPFKEFVKNRDKWALNNLYLYPGPVQYFGSSEIVDEITETLKLEL
3D structure
PDB1kzh The structure of a pyrophosphate-dependent phosphofructokinase from the Lyme disease spirochete Borrelia burgdorferi.
ChainA
Resolution2.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G82 G145 R146 D176 D177 K203 T204 D206 D208 R253
Catalytic site (residue number reindexed from 1) G79 G142 R143 D173 D174 K200 T201 D203 D205 R250
Enzyme Commision number 2.7.1.90: diphosphate--fructose-6-phosphate 1-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A R146 R431 R143 R428
BS02 SO4 A K71 A72 N104 K68 A69 N101
BS03 SO4 A T241 K243 Y244 T238 K240 Y241
Gene Ontology
Molecular Function
GO:0003872 6-phosphofructokinase activity
GO:0005524 ATP binding
GO:0008443 phosphofructokinase activity
GO:0016301 kinase activity
GO:0046872 metal ion binding
GO:0047334 diphosphate-fructose-6-phosphate 1-phosphotransferase activity
Biological Process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006096 glycolytic process
GO:0009749 response to glucose
GO:0016310 phosphorylation
GO:0046835 carbohydrate phosphorylation
GO:0061615 glycolytic process through fructose-6-phosphate
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1kzh, PDBe:1kzh, PDBj:1kzh
PDBsum1kzh
PubMed12015149
UniProtP70826|PFP_BORBU Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (Gene Name=pfp)

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