Structure of PDB 1kyq Chain A

Receptor sequence
>1kyqA (length=262) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MVKSLQLAHQLKDKRILLIGGGEVGLTRLYKLMPTGCKLTLVSPDLHKSI
IPKFGKFIQKRFINPNWDPTKNEIYEYIRSDFKDEYLDLENENDAWYIIM
TCIPDHPESARIYHLCKERFGKQQLVNVADKPDLCDFYFGANLEIGDRLQ
ILISTNGLSPRFGALVRDEIRNLFTQMGDLALEDAVVKLGELRRGIRLLA
PDDKDVKYRMDWARRCTDLFGIQHCHNIDVKRLLDLFKVMFQEQNCSLQF
PPRERLLSEYCS
3D structure
PDB1kyq The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D141
Catalytic site (residue number reindexed from 1) D130
Enzyme Commision number 1.3.1.76: precorrin-2 dehydrogenase.
4.99.1.4: sirohydrochlorin ferrochelatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A G21 G22 E23 V24 S43 P44 D45 D92 F93 I114 P115 G21 G22 E23 V24 S43 P44 D45 D81 F82 I103 P104
Gene Ontology
Molecular Function
GO:0004325 ferrochelatase activity
GO:0016491 oxidoreductase activity
GO:0016829 lyase activity
GO:0043115 precorrin-2 dehydrogenase activity
GO:0051266 sirohydrochlorin ferrochelatase activity
Biological Process
GO:0000103 sulfate assimilation
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0019354 siroheme biosynthetic process
Cellular Component
GO:0005575 cellular_component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1kyq, PDBe:1kyq, PDBj:1kyq
PDBsum1kyq
PubMed11980703
UniProtP15807|MET8_YEAST Siroheme biosynthesis protein MET8 (Gene Name=MET8)

[Back to BioLiP]