Structure of PDB 1kws Chain A

Receptor sequence
>1kwsA (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
MTIYVVTPTYARLVQKAELVRLSQTLSLVPRLHWLLVEDAEGPTPLVSGL
LAASGLLFTHLVVLTPWVHPRGVEQRNKALDWLRGRGGAVGGEKDPPPPG
TQGVVYFADDDNTYSRELFEEMRWTRGVSVWPVGLVGGLRFEGPQVQDGR
VVGFHTAWEPSRPFPVDMAGFAVALPLLLDKPNAQFDSTAPRGHLESSLL
SHLVDPKDLEPRAANCTRVLVWHTRTEKPKMKQEEQLQRQGRGSDPAIEV
3D structure
PDB1kws Crystal structure of beta 1,3-glucuronyltransferase I in complex with active donor substrate UDP-GlcUA.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D196 E281
Catalytic site (residue number reindexed from 1) D111 E196
Enzyme Commision number 2.4.1.135: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D196 H308 R310 D111 H223 R225
BS02 UGA A P82 T83 Y84 D113 R156 R161 D194 D195 D196 D252 M253 H308 R310 P8 T9 Y10 D39 R71 R76 D109 D110 D111 D167 M168 H223 R225
Gene Ontology
Molecular Function
GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1kws, PDBe:1kws, PDBj:1kws
PDBsum1kws
PubMed11950836
UniProtO94766|B3GA3_HUMAN Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (Gene Name=B3GAT3)

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