Structure of PDB 1kwk Chain A

Receptor sequence
>1kwkA (length=644) Species: 274 (Thermus thermophilus) [Search protein sequence]
MLGVCYYPEHWPKERWKEDARRMREAGLSHVRIGEFAWALLEPEPGRLEW
GWLDEAIATLAAEGLKVVLGTPTATPPKWLVDRYPEILPVDREGRRRRFG
GRRHYCFSSPVYREEARRIVTLLAERYGGLEAVAGFQTDNEYGCHDTVRC
YCPRCQEAFRGWLEARYGTIEALNEAWGTAFWSQRYRSFAEVELPHLTVA
EPNPSHLLDYYRFASDQVRAFNRLQVEILRAHAPGKFVTHNFMGFFTDLD
AFALAQDLDFASWDSYPLGFTDLMPLPPEEKLRYARTGHPDVAAFHHDLY
RGVGRGRFWVMEQQPGPVNWAPHNPSPAPGMVRLWTWEALAHGAEVVSYF
RWRQAPFAQEQMHAGLHRPDSAPDQGFFEAKRVAEELAALALPPVAQAPV
ALVFDYEAAWIYEVQPQGAEWSYLGLVYLFYSALRRLGLDVDVVPPGASL
RGYAFAVVPSLPIVREEALEAFREAEGPVLFGPRSGSKTETFQIPKELPP
GPLQALLPLKVVRVESLPPGLLEVAEGALGRFPLGLWREWVEAPLKPLLT
FQDGKGALYREGRYLYLAAWPSPELAGRLLSALAAEAGLKVLSLPEGLRL
RRRGTWVFAFNYGPEAVEAPASEGARFLLGSRRVGPYDLAVWEE
3D structure
PDB1kwk Trimeric crystal structure of the glycoside hydrolase family 42 beta-galactosidase from Thermus thermophilus A4 and the structure of its complex with galactose.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.23: beta-galactosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL A F36 R102 N140 E141 Y266 E312 W320 F350 E360 H363 F36 R102 N140 E141 Y266 E312 W320 F350 E360 H363
BS02 ZN A C106 C152 C106 C152
Gene Ontology
Molecular Function
GO:0004565 beta-galactosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006012 galactose metabolic process
Cellular Component
GO:0009341 beta-galactosidase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1kwk, PDBe:1kwk, PDBj:1kwk
PDBsum1kwk
PubMed12215416
UniProtO69315|BGAL_THETH Beta-galactosidase

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