Structure of PDB 1kvk Chain A

Receptor sequence
>1kvkA (length=378) Species: 10116 (Rattus norvegicus) [Search protein sequence]
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLVLRPQSNGKVS
LNLPNVGIKQVWDVATLQLLDTEKLKKVAGLPRDCVGNEGLSLLAFLYLY
LAICRKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTACEEVTN
PLKDRGSIGSWPEEDLKSINKWAYEGERVIHGNPSGVDNSVSTWGGALRY
QQGKMSSLKRLPALQILLTNTKVPRSTKALVAGVRSRLIKFPEIMAPLLT
SIDAISLECERVLGEMAAAPVPEQYLVLEELMDMNQHHLNALGVGHASLD
QLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLERAKVEAAKQALTGCGFD
CWETSIGAPGVSMHSATSIEDPVRQALG
3D structure
PDB1kvk The Structure of a Binary complex between a Mammalian Mevalonate Kinase and ATP: Insights into the Reaction Mechanism and Human Inherited Disease
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.36: mevalonate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A G144 S146 A147 E193 H197 D204 G128 S130 A131 E177 H181 D188
BS02 ATP A N104 E105 S108 G140 G142 G144 S145 S146 I196 N88 E89 S92 G124 G126 G128 S129 S130 I180
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003729 mRNA binding
GO:0004496 mevalonate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:1990825 sequence-specific mRNA binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0006720 isoprenoid metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0016125 sterol metabolic process
GO:0016310 phosphorylation
GO:0017148 negative regulation of translation
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0045540 regulation of cholesterol biosynthetic process
GO:0050728 negative regulation of inflammatory response
Cellular Component
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1kvk, PDBe:1kvk, PDBj:1kvk
PDBsum1kvk
PubMed11877411
UniProtP17256|KIME_RAT Mevalonate kinase (Gene Name=Mvk)

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