Structure of PDB 1ksg Chain A

Receptor sequence
>1ksgA (length=180) Species: 10090 (Mus musculus) [Search protein sequence]
SMGLLTILKKMKQKERELRLLMLGLDNAGKTTILKKFNGEDVDTISPTLG
FNIKTLEHRGFKLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSADRQRM
QDCQRELQSLLVEERLAGATLLIFANKQDLPGALSCNAIQEALELDSIRS
HHWRIQGCSAVTGEDLLPGIDWLLDDISSR
3D structure
PDB1ksg The complex of Arl2-GTP and PDE delta: from structure to function.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q70
Catalytic site (residue number reindexed from 1) Q71
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T30 T47 T31 T48
BS02 GTP A D25 N26 G28 K29 T30 T31 P46 T47 N125 K126 D128 S158 A159 V160 D26 N27 G29 K30 T31 T32 P47 T48 N126 K127 D129 S159 A160 V161
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
Biological Process
GO:0006110 regulation of glycolytic process
GO:0007098 centrosome cycle
GO:0010811 positive regulation of cell-substrate adhesion
GO:0031113 regulation of microtubule polymerization
GO:0031116 positive regulation of microtubule polymerization
GO:0034260 negative regulation of GTPase activity
GO:0051457 maintenance of protein location in nucleus
GO:0070830 bicellular tight junction assembly
GO:1903715 regulation of aerobic respiration
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0016328 lateral plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ksg, PDBe:1ksg, PDBj:1ksg
PDBsum1ksg
PubMed11980706
UniProtQ9D0J4|ARL2_MOUSE ADP-ribosylation factor-like protein 2 (Gene Name=Arl2)

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