Structure of PDB 1kp2 Chain A

Receptor sequence
>1kp2A (length=431) Species: 562 (Escherichia coli) [Search protein sequence]
TTILKHLPVGQRIGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEE
DYDAIPRRAMEYGAENARLIDCRKQLVAEGIAAIQCGAFHNTTGGLTYFN
TTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAEL
QIYKPWLDTDFIDELGGRHEMSEFMIACGFDYEKAYSTDSNMLGATHEAK
DLEYLNSSVKIVNPIMGVKFWDESVKIPAEEVTVRFEQGHPVALNGKTFS
DDVEMMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYE
RLLTGIHNEDTIEQYHAHGRQLGRLLYQGRWFDSQALMLRDSLQRWVASQ
ITGEVTLELRRGNDYSILNTVSENLTYKPERVFSPDDRIGQLTMRNLDIT
DTREKLFGYAKTGLLSSSAASGVPQVENLEN
3D structure
PDB1kp2 Substrate Induced Conformational Changes in Argininosuccinate Synthetase
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D22 R106 D135 S191
Catalytic site (residue number reindexed from 1) D22 R106 D135 S187
Enzyme Commision number 6.3.4.5: argininosuccinate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A A16 A42 D127 G128 S129 T130 D135 F139 D193 A16 A42 D127 G128 S129 T130 D135 F139 D189
Gene Ontology
Molecular Function
GO:0004055 argininosuccinate synthase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000050 urea cycle
GO:0000053 argininosuccinate metabolic process
GO:0006526 L-arginine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1kp2, PDBe:1kp2, PDBj:1kp2
PDBsum1kp2
PubMed11809762
UniProtP0A6E4|ASSY_ECOLI Argininosuccinate synthase (Gene Name=argG)

[Back to BioLiP]