Structure of PDB 1koq Chain A

Receptor sequence
>1koqA (length=222) Species: 485 (Neisseria gonorrhoeae) [Search protein sequence]
THWGYTGHDSPESWGNLSEEFRLCSTGKNQSPVNITETVSGKLPAIKVNY
KPSMVDVENNGHTIQVNYPEGGNTLTVNGRTYTLKQFHFHVPSENQIKGR
TFPMEAHFVHLDENKQPLVLAVLYEAGKTNGRLSSIWNVMPMTAGKVKLN
QPFDASTLLPKRLKYYRFAGSLTTPPCTEGVSWLVLKTYDHIDQAQAEKF
TRAVGSENNRPVQPLNARVVIE
3D structure
PDB1koq Crystal structure of carbonic anhydrase from Neisseria gonorrhoeae and its complex with the inhibitor acetazolamide.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H66 H92 H94 E98 H111 T177
Catalytic site (residue number reindexed from 1) H62 H88 H90 E94 H107 T173
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H92 H94 H111 H88 H90 H107
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0046872 metal ion binding
Cellular Component
GO:0042597 periplasmic space

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Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:1koq, PDBe:1koq, PDBj:1koq
PDBsum1koq
PubMed9761692
UniProtQ50940|CAH_NEIGO Carbonic anhydrase (Gene Name=cah)

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