Structure of PDB 1kmn Chain A

Receptor sequence
>1kmnA (length=379) Species: 562 (Escherichia coli) [Search protein sequence]
NIQAIRGMNDYLPGETAIWQRIEGTLKNVLGSYGYSEIRLPIVEQTPLFK
RAIGEVTDVVEKEMYTFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQ
RLWYIGPMFRHERPQKGRYRQFHQLGCEVFGLQGPDIDAELIMLTARWWR
ALGISEHVTLELNSIGSLEARANYRDALVAFLYLDEESREHFAGLCKLLE
SAGIAYTVNQRLVRGLDYYNRTVFEWVTNSLGSQGTVCAGGRYDGLVEQL
GGRATPAVGFAMGLERLVLLVQAVNPEFKADPVVDIYLVASGADTQSAAM
ALAERLRDELPGVKLMTNHGGGNFKKQFARADKWGARVAVVLGESEVANG
TAVVKDLRSGEQTAVAQDSVAAHLRTLLG
3D structure
PDB1kmn The first step of aminoacylation at the atomic level in histidyl-tRNA synthetase.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.21: histidine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HSO A E83 T85 E131 Y263 Y264 Y288 G304 F305 A306 E80 T82 E128 Y218 Y219 Y243 G259 F260 A261
BS02 ATP A R113 G120 R121 Y122 F125 Q127 R259 T281 G308 R311 R110 G117 R118 Y119 F122 Q124 R214 T236 G263 R266
Gene Ontology
Molecular Function
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004821 histidine-tRNA ligase activity
GO:0005524 ATP binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006412 translation
GO:0006427 histidyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:1kmn, PDBe:1kmn, PDBj:1kmn
PDBsum1kmn
PubMed9207058
UniProtP60906|SYH_ECOLI Histidine--tRNA ligase (Gene Name=hisS)

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