Structure of PDB 1kk1 Chain A

Receptor sequence
>1kk1A (length=397) Species: 29292 (Pyrococcus abyssi) [Search protein sequence]
SRQAEVNIGMVGHVDHGKTTLTKALTGVWTDSEELRRGITIKIGFADAEI
RRCPNCGRYSTSPVCPYCGHETEFVRRVSFIDAPGHEALMTTMLAGASLM
DGAILVIAANEPCPRPQTREHLMALQIIGQKNIIIAQNKIELVDKEKALE
NYRQIKEFIEGTVAENAPIIPISALHGANIDVLVKAIEDFIPTPKRDPNK
PPKMLVLRSFDVNKPGKLVGGVLDGSIVQGKLKVGDEIEIRPGVPYEEHG
RIKYEPITTEIVSLQAGGQFVEEAYPGGLVGVGTKLDPYLTKGDLMAGNV
VGKPGKLPPVWDSLRLEVHLLERVVEQELKVEPIKRKEVLLLNVGTARTM
GLVTGLGKDEIEVKLQIPVCAEPGDRVAISRQIGSRWRLIGYGIIKE
3D structure
PDB1kk1 The large subunit of initiation factor aIF2 is a close structural homologue of elongation factors.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D20 K23 T24 T47 H93
Catalytic site (residue number reindexed from 1) D15 K18 T19 T40 H86
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C60 C63 C72 C75 C53 C56 C65 C68
BS02 GNP A V19 D20 G22 K23 T24 T25 N145 K146 E148 L149 S180 L182 V14 D15 G17 K18 T19 T20 N138 K139 E141 L142 S173 L175
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1kk1, PDBe:1kk1, PDBj:1kk1
PDBsum1kk1
PubMed11927566
UniProtQ9V1G0|IF2G_PYRAB Translation initiation factor 2 subunit gamma (Gene Name=eif2g)

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