Structure of PDB 1kk0 Chain A

Receptor sequence

>1kk0A (length=399) Species: 29292 (Pyrococcus abyssi)

SRQAEVNIGMVGHVDHGKTTLTKALTGVWTDHSEELRRGITIKIGFADAE
IRRCPNCGRYSTSPVCPYCGHETEFVRRVSFIDAPGHEALMTTMLAGASL
MDGAILVIAANEPCPRPQTREHLMALQIIGQKNIIIAQNKIELVDKEKAL
ENYRQIKEFIEGTVAENAPIIPISALHGANIDVLVKAIEDFIPTPKRDPN
KPPKMLVLRSFDVNKPGLVGGVLGGSIVQGKLKVGDEIEIRPGVPYEEHG
RIKYEPITTEIVSLQAGGQFVEEAYPGGLVGVGTKLDPYLTKGDLMAGNV
VGKPGKLPPVWDSLRLEVHLLERVVGTEQELKVEPIKRKEVLLLNVGTAR
TMGLVTGLGKDEIEVKLQIPVCAEPGDRVAISRQIGSRWRLIGYGIIKE

3D structure

• PDB: 1kk0 The large subunit of initiation factor aIF2 is a close structural homologue of elongation factors.
• Chain: A
• Resolution: 1.95 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D20 K23 T24 T47 H93
• Catalytic site (residue number reindexed from 1): D15 K18 T19 T41 H87
• Enzyme Commision number: 3.6.5.3: protein-synthesizing GTPase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	C60 C63 C72 C75	C54 C57 C66 C69

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003743 translation initiation factor activity
• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0001731 formation of translation preinitiation complex
• GO:0006412 translation
• GO:0006413 translational initiation
• GO:0006414 translational elongation

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:1kk0, PDBe:1kk0, PDBj:1kk0
• PDBsum: 1kk0
• PubMed: 11927566
• UniProt: Q9V1G0|IF2G_PYRAB Translation initiation factor 2 subunit gamma (Gene Name=eif2g)