Structure of PDB 1kh8 Chain A

Receptor sequence
>1kh8A (length=125) Species: 9913 (Bos taurus) [Search protein sequence]
MKETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHE
SLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKT
TQANKHIIVACEGNGYVPVHFDASV
3D structure
PDB1kh8 The crystal structure of the cis-proline to glycine variant (P114G) of ribonuclease A.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H12 K41 H119 F120 D121
Catalytic site (residue number reindexed from 1) H13 K42 H120 F121 D122
Enzyme Commision number 4.6.1.18: pancreatic ribonuclease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CS A C58 Y73 N113 G114 Y115 C59 Y74 N114 G115 Y116
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004519 endonuclease activity
GO:0004522 ribonuclease A activity
GO:0004540 RNA nuclease activity
GO:0005515 protein binding
GO:0016829 lyase activity
Biological Process
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region

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Cellular Component
External links
PDB RCSB:1kh8, PDBe:1kh8, PDBj:1kh8
PDBsum1kh8
PubMed16199662
UniProtP61823|RNAS1_BOVIN Ribonuclease pancreatic (Gene Name=RNASE1)

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