Structure of PDB 1kea Chain A

Receptor sequence
>1keaA (length=217) Species: 145262 (Methanothermobacter thermautotrophicus) [Search protein sequence]
DATNKKRKVFVSTILTFWNTDRRDFPWRHTRDPYVILITEILLRRTTAGH
VKKIYDKFFVKYKCFEDILKTPKSEIAKDIKEIGLSNQRAEQLKELARVV
INDYGGRVPRNRKAILDLPGVGKYTCAAVMCLAFGKKAAMVDANFVRVIN
RYFGGSYENLNYNHKALWELAETLVPGGKCRDFNLGLMDFSAIICAPRKP
KCEKCGMSKLCSYYEKC
3D structure
PDB1kea Structure and activity of a thermostable thymine-DNA glycosylase: evidence for base twisting to remove mismatched normal DNA bases.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E42 Y126 D144
Catalytic site (residue number reindexed from 1) E40 Y124 D142
Enzyme Commision number 3.2.2.-
3.2.2.29: thymine-DNA glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C66 E68 C64 E66
BS02 SF4 A R153 C197 P202 C204 C207 S210 C213 Y215 R151 C195 P200 C202 C205 S208 C211 Y213
Gene Ontology
Molecular Function
GO:0000701 purine-specific mismatch base pair DNA N-glycosylase activity
GO:0003824 catalytic activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0032357 oxidized purine DNA binding
GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
GO:0035485 adenine/guanine mispair binding
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0141016 G/T mismatch-specific thymine-DNA glycosylase activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006298 mismatch repair
GO:0006950 response to stress

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Molecular Function
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Biological Process
External links
PDB RCSB:1kea, PDBe:1kea, PDBj:1kea
PDBsum1kea
PubMed11786018
UniProtP29588|MIG_METTF Thymine/uracil-DNA glycosylase (Gene Name=mig)

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