Structure of PDB 1kdm Chain A

Receptor sequence
>1kdmA (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
DPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTN
PKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDS
VLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPAL
DGCLRRDSWLDKQAEISASAPTSLRSC
3D structure
PDB1kdm Resolution of a disordered region at the entrance of the human sex hormone-binding globulin steroid-binding site.
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D50 E52 A160 D39 E41 A149
BS02 DHT A T40 S41 S42 D65 F67 N82 K134 M139 T29 S30 S31 D54 F56 N71 K123 M128 BindingDB: IC50=3.8nM,Kd=0.182000nM
External links
PDB RCSB:1kdm, PDBe:1kdm, PDBj:1kdm
PDBsum1kdm
PubMed12054810
UniProtP04278|SHBG_HUMAN Sex hormone-binding globulin (Gene Name=SHBG)

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