Structure of PDB 1kc6 Chain A

Receptor sequence
>1kc6A (length=249) Species: 727 (Haemophilus influenzae) [Search protein sequence]
SFIKPIYQDINSILIGQKVKRPAAGEPFEKLVYKFLKENLSDLTFKQYEY
LNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQ
NDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNK
EFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQ
FHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYIL
3D structure
PDB1kc6 Sequence selectivity and degeneracy of a restriction endonuclease mediated by DNA intercalation.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.21.4: type II site-specific deoxyribonuclease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K93 Q109 Q138 Y199 N201 A204 K84 Q100 Q129 Y190 N192 A195
BS02 dna A Q109 N110 D127 T130 N132 K135 S136 A137 A139 P140 N141 S144 Y146 K147 A205 M206 Q207 Q100 N101 D118 T121 N123 K126 S127 A128 A130 P131 N132 S135 Y137 K138 A196 M197 Q198
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0009036 type II site-specific deoxyribonuclease activity
Biological Process
GO:0009307 DNA restriction-modification system

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Molecular Function
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Biological Process
External links
PDB RCSB:1kc6, PDBe:1kc6, PDBj:1kc6
PDBsum1kc6
PubMed11742344
UniProtP17743|T2C2_HAEIF Type II restriction enzyme HincII (Gene Name=hincIIR)

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