Structure of PDB 1k9z Chain A

Receptor sequence
>1k9zA (length=354) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
ALERELLVATQAVRKASLLTKRIQSEVISHKDSTTITKNDNSPVTTGDYA
AQTIIINAIKSNFPDDKVVGEESSSGLSDAFVSGILNEIKANDEVYNKNY
KKDDFLFTNDQFPLKSLEDVRQIIDFGNYEGGRKGRFWCLDPIDGTKGFL
RGEQFAVCLALIVDGVVQLGCIGCPNLVLSSYGAQDLKGHESFGYIFRAV
RGLGAFYSPSSDAESWTKIHVRHLKDTKDMITLEGVEKGHSSHDEQTAIK
NKLNISKSLHLDSQAKYCLLALGLADVYLRLPIKLSYQEKIWDHAAGNVI
VHEAGGIHTDAMEDVPLDFGNGRTLATKGVIASSGPRELHDLVVSTSCDV
IQSR
3D structure
PDB1k9z Hal2p: Ion selectivity and implications on inhibition mechanism
ChainA
Resolution1.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D49 E72 D142 I144 D145 T147 D294
Catalytic site (residue number reindexed from 1) D48 E71 D141 I143 D144 T146 D293
Enzyme Commision number 3.1.3.7: 3'(2'),5'-bisphosphate nucleotidase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 ZN A E72 D142 I144 E71 D141 I143
BS02 ZN A D142 D145 D294 D141 D144 D293
BS03 ZN A E27 E89 E26 E88
BS04 ZN A H221 H224 H220 H223
BS05 ZN A E235 H244 H261 E234 H243 H260
BS06 ZN A D315 D342 D314 D341
Gene Ontology
Molecular Function
GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0000103 sulfate assimilation
GO:0006790 sulfur compound metabolic process
GO:0009086 methionine biosynthetic process
GO:0016078 tRNA decay
GO:0042538 hyperosmotic salinity response
GO:0046854 phosphatidylinositol phosphate biosynthetic process
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:1k9z, PDBe:1k9z, PDBj:1k9z
PDBsum1k9z
PubMed
UniProtP32179|MET22_YEAST 3'(2'),5'-bisphosphate nucleotidase (Gene Name=MET22)

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