Structure of PDB 1k8r Chain A

Receptor sequence
>1k8rA (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQI
KRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQ
GVEDAFYTLVREIRQH
3D structure
PDB1k8r The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A K16 S17 T35 D57 K16 S17 T35 D57
BS02 GNP A G13 G15 K16 S17 A18 F28 V29 D30 E31 Y32 T35 G60 N116 K117 D119 L120 S145 A146 G13 G15 K16 S17 A18 F28 V29 D30 E31 Y32 T35 G60 N116 K117 D119 L120 S145 A146
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:1k8r, PDBe:1k8r, PDBj:1k8r
PDBsum1k8r
PubMed11709168
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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