Structure of PDB 1k8q Chain A

Receptor sequence
>1k8qA (length=377) Species: 9615 (Canis lupus familiaris) [Search protein sequence]
AFGKLHPTNPEVTMNISQMITYWGYPAEEYEVVTEDGYILGIDRIPYGRK
NSENIGRRPVAFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSR
GNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFILKKTGQDKLHYV
GHSQGTTIGFIAFSTNPKLAKRIKTFYALAPVATVKYTETLINKLMLVPS
FLFKLIFGNKIFYPHHFFDQFLATEVCSRETVDLLCSNALFIICGFDTMN
LNMSRLDVYLSHNPAGTSVQNVLHWSQAVKSGKFQAFDWGSPVQNMMHYH
QSMPPYYNLTDMHVPIAVWNGGNDLLADPHDVDLLLSKLPNLIYHRKIPP
YNHLDFIWAMDAPQAVYNEIVSMMGTD
3D structure
PDB1k8q Crystal structure of the open form of dog gastric lipase in complex with a phosphonate inhibitor.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.3: triacylglycerol lipase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C11 A G66 L67 S153 Q154 I192 M196 W275 L326 H353 G66 L67 S153 Q154 I192 M196 W275 L326 H353
Gene Ontology
Molecular Function
GO:0004806 triacylglycerol lipase activity
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
Biological Process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1k8q, PDBe:1k8q, PDBj:1k8q
PDBsum1k8q
PubMed11689574
UniProtP80035|LIPF_CANLF Gastric triacylglycerol lipase (Gene Name=LIPF)

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