Structure of PDB 1k74 Chain A

Receptor sequence
>1k74A (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
NEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQL
FTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILL
ATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLF
NPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALR
SIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAP
3D structure
PDB1k74 Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F277 V280 K284 L294 V298 R302 T449 F450 E453 E456 F51 V54 K58 L68 V72 R76 T223 F224 E227 E230
BS02 9CR A I268 A272 Q275 W305 F313 R316 L326 A327 C432 L436 I42 A46 Q49 W79 F87 R90 L100 A101 C206 L210 BindingDB: EC50=100nM,Ki=583nM,IC50=32nM,Kd=240nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:1k74, PDBe:1k74, PDBj:1k74
PDBsum1k74
PubMed11698662
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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