Structure of PDB 1k4j Chain A

Receptor sequence
>1k4jA (length=193) Species: 66271 (Pantoea stewartii subsp. stewartii) [Search protein sequence]
HMLELFDVSYEELRLGWEVICSQGMESDEFDGPGTRYILGICEGQLVCSV
RFTSLDRPNMITHTFQHCFSDVTLPAYGTESSRFFVDKARARALLGEHYP
ISQVLFLAMVNWAQNNAYGNIYTIVSRAMLKILTRSGWQIKVIKEAFLTE
KERIYLLTLPAGQDDKQQLGGDVVSRTGCPPVAVTTWPLTLPV
3D structure
PDB1k4j Structural basis and specificity of acyl-homoserine lactone signal production in bacterial quorum sensing.
ChainA
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.1.184: acyl-homoserine-lactone synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 REO A P117 S119 P100 S102
BS02 REO A C85 K161 A163 F164 C68 K144 A146 F147
BS03 REO A V142 S143 M146 V125 S126 M129
BS04 REO A S119 I149 S102 I132
BS05 REO A H115 R193 H98 R176
BS06 REO A G51 F69 T70 S71 T96 Y135 G34 F52 T53 S54 T79 Y118
BS07 REO A I141 V142 I124 V125
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0061579 N-acyl homoserine lactone synthase activity
Biological Process
GO:0007165 signal transduction
GO:0009372 quorum sensing

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1k4j, PDBe:1k4j, PDBj:1k4j
PDBsum1k4j
PubMed11931774
UniProtP54656|ESAI_PANSE Acyl-homoserine-lactone synthase (Gene Name=esaI)

[Back to BioLiP]