Structure of PDB 1k2f Chain A

Receptor sequence
>1k2fA (length=190) Species: 10090 (Mus musculus) [Search protein sequence]
SVLFPCKYASSGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGSLD
AVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLV
LEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRS
IHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
3D structure
PDB1k2f Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C128 C135 H147 H152 C36 C43 H55 H60
BS02 ZN A D200 H202 D108 H110
BS03 ZN A H230 E269 H138 E177
BS04 ZN A H117 C121 H25 C29
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007275 multicellular organism development
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1k2f, PDBe:1k2f, PDBj:1k2f
PDBsum1k2f
PubMed11742346
UniProtP61092|SIA1A_MOUSE E3 ubiquitin-protein ligase SIAH1A (Gene Name=Siah1a)

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