Structure of PDB 1k0c Chain A

Receptor sequence
>1k0cA (length=228) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
ITKFFQEQPLEGYTLFSHRSAPNGFKVAIVLSELGFHYNTIFLDFNLGEH
RAPEFVSVNPNARVPALIDHGMDNLSIWESGAILLHLVNKYYKETGNPLL
WSDDLADQSQINAWLFFQTSGHAPMIGQALHFRYFHSQKIASAVERYTDE
VRRVYGVVEMALAERREALVMFDYPVWLVGDKLTIADLAFVPWNNVVDRI
GINIKIEFPEVYKWTKHMMRRPAVIKAL
3D structure
PDB1k0c Crystal structures of the yeast prion Ure2p functional region in complex with glutathione and related compounds.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A122
Catalytic site (residue number reindexed from 1) A21
Enzyme Commision number 1.11.1.9: glutathione peroxidase.
1.8.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTB A S121 A122 P123 N124 F146 R164 V165 E180 S181 L231 W316 V319 R322 S20 A21 P22 N23 F45 R63 V64 E79 S80 L130 W193 V196 R199
Gene Ontology
Molecular Function
GO:0003714 transcription corepressor activity
Biological Process
GO:0006808 regulation of nitrogen utilization

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Molecular Function
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Biological Process
External links
PDB RCSB:1k0c, PDBe:1k0c, PDBj:1k0c
PDBsum1k0c
PubMed11695904
UniProtP23202|URE2_YEAST Transcriptional regulator URE2 (Gene Name=URE2)

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