Structure of PDB 1jxp Chain A

Receptor sequence
>1jxpA (length=177) Species: 11105 (Hepatitis C virus (isolate BK)) [Search protein sequence]
ITAYSQQTRGLLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCVNGVC
WTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSS
DLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVG
IFRAAVCTRGVAKAVDFVPVESMETTM
3D structure
PDB1jxp Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H55 D79 G135 S137
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I3 T4 A5 Y6 S7 Q8 T10 R11 T19 S20 E30 E32 V33 Q34 V35 V36 S37 K62 T63 L64 A65 V107 I1 T2 A3 Y4 S5 Q6 T8 R9 T17 S18 E28 E30 V31 Q32 V33 V34 S35 K60 T61 L62 A63 V105
BS02 ZN A C97 C99 C145 C95 C97 C143
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:1jxp, PDBe:1jxp, PDBj:1jxp
PDBsum1jxp
PubMed9568891
UniProtP26663|POLG_HCVBK Genome polyprotein

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