Structure of PDB 1jxi Chain A

Receptor sequence
>1jxiA (length=254) [Search protein sequence]
MQRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAENTCGVQ
SVYRIEPDFVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRHHVR
NVVLDTVMLAKSGDPLLSPSAIETLRVRLLPQVSLITPNLPEAAALLDAP
HARTEQEMLAQGRALLAMGCEAVLMKGDWLFTREGEQRFRVNTKNTHGTG
CTLSAALAALRPRHRSWGETVNEAKAWLSAALAQADTLEVGKGIGPVHHF
HAWW
3D structure
PDB1jxi Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution.
ChainA
Resolution2.64 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K176 T208 G210 T211 G212 C213
Catalytic site (residue number reindexed from 1) K176 T196 G198 T199 G200 C201
Enzyme Commision number 2.7.1.49: hydroxymethylpyrimidine kinase.
2.7.4.7: phosphooxymethylpyrimidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HMH A G11 T12 E44 C213 G11 T12 E44 C201
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0008902 hydroxymethylpyrimidine kinase activity
GO:0008972 phosphomethylpyrimidine kinase activity
GO:0016301 kinase activity
Biological Process
GO:0009228 thiamine biosynthetic process
GO:0009229 thiamine diphosphate biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1jxi, PDBe:1jxi, PDBj:1jxi
PDBsum1jxi
PubMed11839308
UniProtP55882|THID_SALTY Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (Gene Name=thiD)

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