Structure of PDB 1jx2 Chain A

Receptor sequence
>1jx2A (length=1039) Species: 44689 (Dictyostelium discoideum) [Search protein sequence]
DPIHDRTSDYHKYLKVKQFKLTVSDKRYIWYNPDPKERDSYECGEIVSET
SDSFTFKTVDGQDRQVKKDDANQRNPIKFDGVEDMSELSYLNEPAVFHNL
RVRYNQDLIYTYSGLFLVAVNPFKRIPIYTQEMVDIFKGRRRNEVAPHIF
AISDVAYRSMLDDRQNQSLLITGESGAGKTENTKKVIQYLASVAGSGVLE
QQILQANPILEAFGNAKTTRNNNSSRFGKFIEIQFNSAGFISGASIQSYL
LEKSRVVFQSETERNYHIFYQLLAGATAEEKKALHLAGPESFNYLNQSGC
VDIKGVSDSEEFKITRQAMDIVGFSQEEQMSIFKIIAGILHLGNIKFEKG
AGEGAVLKDKTALNAASTVFGVNPSVLEKALMEPRILAGRDLVAQHLNVE
KSSSSRDALVKALYGRLFLWLVKKINNVLCQERKAYFIGVLDISGFEIFK
VNSFEQLCINYTNEKLQQFFNHHMFKLEQEEYLKEKINWTFIDFGLDSQA
TIDLIDGRQPPGILALLDEQSVFPNATDNTLITKLHSHFSKKNAKYEEPR
FSKTEFGVTHYAGQVMYEIQDWLEKNKDPLQQDLELCFKDSSDNVVTKLF
NDPNIASRAKKGANFITVAAQYKEQLASLMATLETTNPHFVRCIIPNNKQ
LPAKLEDKVVLDQLRCNGVLEGIRITRKGFPNRIIYADFVKRYYLLAPNV
PRDAEDSQKATDAVLKHLNIDPEQYRFGITKIFFRAGQLARIEEAREQRI
SEITRGLVDQLIPVINKLQDVFNTLGSDPLDLPQIVVVGSQSSGKSSVLE
NIVGRDFLPRPLILQLTHLPIADDGSQTQEWGEFLHKPNDMFYDFSEIRE
EIIRDTDISAQPINLKIYSPHVVNLTLVDLPGITDIEQQIRRMVMAYIKK
QNAIIVAVTPANTDLANSDALQLAKEVDPEGKRTIGVITKLDLMDKGTDA
MEVLTGRVIPLTLGFIGVINRSQEDIIAKKSIRESLKSEILYFKNHPIYK
SIANRSGTAYLSKTLNKLLMFHIRDTLPDLKVKVSKMLS
3D structure
PDB1jx2 Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S192 G193 T197 N244 S247 S248 G468 E470
Catalytic site (residue number reindexed from 1) S175 G176 T180 N221 S224 S225 G445 E447
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BGC A K488 D529 K646 K465 D506 K623
BS02 MG A T197 S248 T180 S225
BS03 ADP A N138 P139 G193 G195 K196 T197 E198 N244 N121 P122 G176 G178 K179 T180 E181 N221
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0003924 GTPase activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:1jx2, PDBe:1jx2, PDBj:1jx2
PDBsum1jx2
PubMed11689422
UniProtP08799|MYS2_DICDI Myosin-2 heavy chain (Gene Name=mhcA);
Q94464

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