Structure of PDB 1jwy Chain A

Receptor sequence

>1jwyA (length=1039) Species: 44689 (Dictyostelium discoideum)

DPIHDRTSDYHKYLKVKQFKLTVSDKRYIWYNPDPKERDSYECGEIVSET
SDSFTFKTVDGQDRQVKKDDANQRNPIKFDGVEDMSELSYLNEPAVFHNL
RVRYNQDLIYTYSGLFLVAVNPFKRIPIYTQEMVDIFKGRRRNEVAPHIF
AISDVAYRSMLDDRQNQSLLITGESGAGKTENTKKVIQYLASVAGSGVLE
QQILQANPILEAFGNAKTTRNNNSSRFGKFIEIQFNSAGFISGASIQSYL
LEKSRVVFQSETERNYHIFYQLLAGATAEEKKALHLAGPESFNYLNQSGC
VDIKGVSDSEEFKITRQAMDIVGFSQEEQMSIFKIIAGILHLGNIKFEKG
AGEGAVLKDKTALNAASTVFGVNPSVLEKALMEPRILAGRDLVAQHLNVE
KSSSSRDALVKALYGRLFLWLVKKINNVLCQERKAYFIGVLDISGFEIFK
VNSFEQLCINYTNEKLQQFFNHHMFKLEQEEYLKEKINWTFIDFGLDSQA
TIDLIDGRQPPGILALLDEQSVFPNATDNTLITKLHSHFSKKNAKYEEPR
FSKTEFGVTHYAGQVMYEIQDWLEKNKDPLQQDLELCFKDSSDNVVTKLF
NDPNIASRAKKGANFITVAAQYKEQLASLMATLETTNPHFVRCIIPNNKQ
LPAKLEDKVVLDQLRCNGVLEGIRITRKGFPNRIIYADFVKRYYLLAPNV
PRDAEDSQKATDAVLKHLNIDPEQYRFGITKIFFRAGQLARIEEAREQRI
SEITRGLVDQLIPVINKLQDVFNTLGSDPLDLPQIVVVGSQSSGKSSVLE
NIVGRDFLPRPLILQLTHLPIADDGSQTQEWGEFLHKPNDMFYDFSEIRE
EIIRDTDISAQPINLKIYSPHVVNLTLVDLPGITDIEQQIRRMVMAYIKK
QNAIIVAVTPANTDLANSDALQLAKEVDPEGKRTIGVITKLDLMDKGTDA
MEVLTGRVIPLTLGFIGVINRSQEDIIAKKSIRESLKSEILYFKNHPIYK
SIANRSGTAYLSKTLNKLLMFHIRDTLPDLKVKVSKMLS

3D structure

• PDB: 1jwy Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms.
• Chain: A
• Resolution: 2.3 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): S192 G193 T197 N244 S247 S248 G468 E470
• Catalytic site (residue number reindexed from 1): S175 G176 T180 N221 S224 S225 G445 E447

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BGC	A	K488 D529 R531 K646	K465 D506 R508 K623
BS02	MG	A	T197 S248	T180 S225
BS03	ADP	A	N138 P139 G193 G195 K196 T197 E198 N244	N121 P122 G176 G178 K179 T180 E181 N221
BS04	GDP	A	S819 S820 G821 K822 S823 S824 K992 D994 L995 N1022 R1023 S1024 Q1025	S792 S793 G794 K795 S796 S797 K940 D942 L943 N970 R971 S972 Q973

Gene Ontology

Molecular Function

• GO:0003774 cytoskeletal motor activity
• GO:0003924 GTPase activity
• GO:0005524 ATP binding
• GO:0005525 GTP binding
• GO:0051015 actin filament binding

Cellular Component

• GO:0016459 myosin complex

External links

• PDB: RCSB:1jwy, PDBe:1jwy, PDBj:1jwy
• PDBsum: 1jwy
• PubMed: 11689422
• UniProt: P08799|MYS2_DICDI Myosin-2 heavy chain (Gene Name=mhcA);
  Q94464