Structure of PDB 1jwl Chain A

Receptor sequence
>1jwlA (length=329) Species: 562 (Escherichia coli) [Search protein sequence]
KPVTLYDVAEYAGVSYQTVSRVVNQASHVSAKTREKVEAAMAELNYIPNR
VAQQLAGKQSLLIGVATSSLALHAPSQIVAAIKSRADQLGASVVVSMVER
SGVEACKTAVHNLLAQRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVS
DQTPINSIIFSHEDGTRLGVEHLVALGHQQIALLAGPLSSVSARLRLAGW
HKYLTRNQIQPIAEREGDWSAMSGFQQTMQMLNEGIVPTAMLVANDQMAL
GAMRAITESGLRVGADISVVGYDDTEDSSCYIPPLTTIKQDFRLLGQTSV
DRLLQLSQGQAVKGNQLLPVSLVKRKTTL
3D structure
PDB1jwl Crystallographic analysis of Lac repressor bound to natural operator O1.
ChainA
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A A53 A57 A52 A56
BS02 NPF A A75 F161 R197 W220 D274 A74 F160 R196 W219 D273
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001217 DNA-binding transcription repressor activity
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0042802 identical protein binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1jwl, PDBe:1jwl, PDBj:1jwl
PDBsum1jwl
PubMed11580238
UniProtP03023|LACI_ECOLI Lactose operon repressor (Gene Name=lacI)

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