Structure of PDB 1juv Chain A

Receptor sequence
>1juvA (length=193) Species: 10665 (Tequatrovirus T4) [Search protein sequence]
MIKLVFRYSPTKTVDGFNELAFGLGDGLPWGRVKKDLQNFKARTEGTIMI
MGAKTFQSLPTLLPGRSHIVVCDLARDYPVTKDGDLAHFYITWEQYITYI
SGGEIQVSSPNAPFETMLDQNSKVSVIGGPALLYAALPYADEVVVSRIVK
RHRVNSTVQLDASFLDDISKREMVETHWYKIDEVTTLTESVYK
3D structure
PDB1juv Crystal structure analysis of Dihydrofolate reductase from Bacteriophage T4
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.3: dihydrofolate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP A F6 R7 F22 G23 G25 G27 G52 A53 K54 T55 C72 D73 R76 D77 P79 G129 F6 R7 F22 G23 G25 G27 G52 A53 K54 T55 C72 D73 R76 D77 P79 G129
Gene Ontology
Molecular Function
GO:0004146 dihydrofolate reductase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006730 one-carbon metabolic process
GO:0031427 response to methotrexate
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:1juv, PDBe:1juv, PDBj:1juv
PDBsum1juv
PubMed
UniProtP04382|DYR_BPT4 Dihydrofolate reductase (Gene Name=frd)

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