Structure of PDB 1jrx Chain A

Receptor sequence

>1jrxA (length=568) Species: 56812 (Shewanella frigidimarina) [Search protein sequence]

ADNLAEFHVQNQECDSCHTPDGELSNDSLTYENTQCVSCHGTLAEVAETT
KHEHYNAHASHFPGEVACTSCHSAHEKSMVYCDSCHSFDFNMPYAKKWLR
DEPTIAELAKDKSERQAALASAPHDTVDVVVVGSGGAGFSAAISATDSGA
KVILIEKEPVIGGNAKLAAGGMNAAWTDQQKAKKITDSPELMFEDTMKGG
QNINDPALVKVLSSHSKDSVDWMTAMGADLTDVGMMGGASVNRAHRPTGG
AGVGAHVVQVLYDNAVKRNIDLRMNTRGIEVLKDDKGTVKGILVKGMYKG
YYWVKADAVILATGGFAKNNERVAKLDPSLKGFISTNQPGAVGDGLDVAE
NAGGALKDMQYIQAHPTLSVKGGVMVTEAVRGNGAILVNREGKRFVNEIT
TADKASAAILAQTGKSAYLIFDDSVRKSLSKIDKYIGLGVAPTADSLVKL
GKMEGIDGKALTETVARYNSLVSSGKDTDFERPNLPRALNEGNYYAIEVT
PGVHHTMGGVMIDTKAEVMNAKKQVIPGLYGAGEVTGGVHGANRLGGNAI
SDIITFGRLAGEEAAKYS

3D structure

PDB

1jrx Kinetic and crystallographic analysis of the key active site acid/base arginine in a soluble fumarate reductase.

Chain

Resolution

2.0 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	M236 Q363 H365 M375 E378 R381 A402 H504 H505 R544
Catalytic site (residue number reindexed from 1)	M236 Q363 H365 M375 E378 R381 A402 H504 H505 R544
Enzyme Commision number	1.3.2.4: fumarate reductase (cytochrome).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HEM	A	H8 V9 C14 C17 H18 L24 S73 A74 H75 Y298	H8 V9 C14 C17 H18 L24 S73 A74 H75 Y298
BS02	HEM	A	L4 F7 H8 Q12 S16 C36 C39 H40 H72 Y94	L4 F7 H8 Q12 S16 C36 C39 H40 H72 Y94
BS03	HEM	A	H40 L43 V46 H52 A57 H58 C68 C71 H72 V80 F90 N91 M92	H40 L43 V46 H52 A57 H58 C68 C71 H72 V80 F90 N91 M92
BS04	HEM	A	Y55 S60 H61 F62 C82 C85 H86 F88 L167 Q338 V374 K431 K434 Y435 L438	Y55 S60 H61 F62 C82 C85 H86 F88 L167 Q338 V374 K431 K434 Y435 L438
BS05	FAD	A	V132 G133 G135 A137 E156 K157 G163 N164 A165 L167 A168 A169 G170 G171 R277 G278 T313 T336 Q338 D344 M375 H504 H505 G533 E534 G547 A549 I550 I553	V132 G133 G135 A137 E156 K157 G163 N164 A165 L167 A168 A169 G170 G171 R277 G278 T313 T336 Q338 D344 M375 H504 H505 G533 E534 G547 A549 I550 I553
BS06	FUM	A	G170 M236 H365 M375 T377 E378 H504 R544	G170 M236 H365 M375 T377 E378 H504 R544

Gene Ontology

	Molecular Function
GO:0009055	electron transfer activity
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

	Biological Process
GO:0008202	steroid metabolic process
GO:0009061	anaerobic respiration
GO:0019645	anaerobic electron transport chain

	Cellular Component
GO:0030288	outer membrane-bounded periplasmic space
GO:0042597	periplasmic space

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:1jrx, PDBe:1jrx, PDBj:1jrx
PDBsum	1jrx
PubMed	11591148
UniProt	P0C278\|FCCA_SHEFR Fumarate reductase (cytochrome) (Gene Name=fccA)

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