Structure of PDB 1jrr Chain A

Receptor sequence

>1jrrA (length=357) Species: 9606 (Homo sapiens)

EDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTE
DQMAKVLQFNKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEY
IRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVD
GDTRMVLVNAVYFKGKWKTPFEKKYPFRVNSAQRTPVQMMYLREKLNIGY
IEDLKAQILELPYAGDVSMFLLLPDDVSTGLELLESEITYDKLNKWTSKD
KMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERND
LFLSEVFHQAMVDVNEEGTTGRTGHGGPQFVADHPFLFLIMHKITNCILF
FGRFSSP

3D structure

• PDB: 1jrr CRYSTAL STRUCTURE OF THE COMPLEX OF PLASMINOGEN ACTIVATOR INHIBITOR 2 WITH A PEPTIDE MIMICKING THE REACTIVE CENTER LOOP
• Chain: A
• Resolution: 1.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	S34 T38 K180 L184 D193 R195 M196 V197 L198 V199 N200 A201 V202 Y203 F204 K205 G206 W208 Y258 K335 A338 F340 N347 D348 L349 F350 L351 S352 E353 V354 F355 H356 Q357 A358 M359 V360 D361 N363 F408	S33 T37 K139 L143 D152 R154 M155 V156 L157 V158 N159 A160 V161 Y162 F163 K164 G165 W167 Y213 K287 A290 F292 N299 D300 L301 F302 L303 S304 E305 V306 F307 H308 Q309 A310 M311 V312 D313 N315 F350

Gene Ontology

Molecular Function

• GO:0004867 serine-type endopeptidase inhibitor activity

Biological Process

• GO:0010466 negative regulation of peptidase activity
• GO:0042730 fibrinolysis
• GO:0043066 negative regulation of apoptotic process

Cellular Component

• GO:0001533 cornified envelope
• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0005886 plasma membrane

External links

• PDB: RCSB:1jrr, PDBe:1jrr, PDBj:1jrr
• PDBsum: 1jrr
• PubMed: 11546761
• UniProt: P05120|PAI2_HUMAN Plasminogen activator inhibitor 2 (Gene Name=SERPINB2)