Structure of PDB 1jqa Chain A

Receptor sequence

>1jqaA (length=361) Species: 1422 (Geobacillus stearothermophilus)

AERVFISPAKYVQGKNVITKIANYLEGIGNKTVVIADEIVWKIAGHTIVN
ELKKGNIAAEEVVFSGEASRNEVERIANIARKAEAAIVIGVGGGKTLDTA
KAVADELDAYIVIVPTAASTDAPTSALSVIYVFESYRFYKKNPDLVLVDT
KIIANAPPRLLASGIADALATWVEARSVIKSGGKTMAGGIPTIAAEAIAE
KCEQTLFKYGKLAYESVKAKVVTPALEAVVEANTLLSGLGFESGGLAAAH
AIHNGFTALEGEIHHLTHGEKVAFGTLVQLALEEHSQQEIERYIELYLCL
DLPVTLEDIKLKDASREDILKVAKAATAEGETIHNAFNVTADDVADAIFA
ADQYAKAYKEK

3D structure

• PDB: 1jqa Glycerol dehydrogenase. structure, specificity, and mechanism of a family III polyol dehydrogenase.
• Chain: A
• Resolution: 2.05 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D173 H256 H259 H274
• Catalytic site (residue number reindexed from 1): D167 H250 H253 H268
• Enzyme Commision number: 1.1.1.6: glycerol dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	D173 H256 H274	D167 H250 H268
BS02	ZN	A	E268 H271	E262 H265
BS03	GOL	A	D123 D173 F247 H256 H274	D121 D167 F241 H250 H268

Gene Ontology

Molecular Function

• GO:0008888 glycerol dehydrogenase (NAD+) activity
• GO:0016491 oxidoreductase activity
• GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
• GO:0046872 metal ion binding

Biological Process

• GO:0006071 glycerol metabolic process
• GO:0019588 anaerobic glycerol catabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:1jqa, PDBe:1jqa, PDBj:1jqa
• PDBsum: 1jqa
• PubMed: 11566129
• UniProt: P32816|GLDA_GEOSE Glycerol dehydrogenase (Gene Name=gldA)