Structure of PDB 1jq5 Chain A

Receptor sequence

>1jq5A (length=366) Species: 1422 (Geobacillus stearothermophilus)

AAERVFISPAKYVQGKNVITKIANYLEGIGNKTVVIADEIVWKIAGHTIV
NELKKGNIAAEEVVFSGEASRNEVERIANIARKAEAAIVIGVGGGKTLDT
AKAVADELDAYIVIVPTAASTDAPTSALSVIYSDDGVFESYRFYKKNPDL
VLVDTKIIANAPPRLLASGIADALATWVEARSVIKSGGKTMAGGIPTIAA
EAIAEKCEQTLFKYGKLAYESVKAKVVTPALEAVVEANTLLSGLGFESGG
LAAAHAIHNGFTALEGEIHHLTHGEKVAFGTLVQLALEEHSQQEIERYIE
LYLCLDLPVTLEDIKLKDASREDILKVAKAATAEGETIHNAFNVTADDVA
DAIFAADQYAKAYKEK

3D structure

• PDB: 1jq5 Glycerol dehydrogenase. structure, specificity, and mechanism of a family III polyol dehydrogenase.
• Chain: A
• Resolution: 1.7 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D173 H256 H259 H274
• Catalytic site (residue number reindexed from 1): D172 H255 H258 H273
• Enzyme Commision number: 1.1.1.6: glycerol dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	D173 H256 H274	D172 H255 H273
BS02	ZN	A	E268 H271	E267 H270
BS03	NAD	A	D39 I45 G95 G96 K97 D100 T118 S121 T122 D123 A124 S127 L129 V131 Y133 A162 P163 H274	D38 I44 G94 G95 K96 D99 T117 S120 T121 D122 A123 S126 L128 V130 Y132 A161 P162 H273

Gene Ontology

Molecular Function

• GO:0008888 glycerol dehydrogenase (NAD+) activity
• GO:0016491 oxidoreductase activity
• GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
• GO:0046872 metal ion binding

Biological Process

• GO:0006071 glycerol metabolic process
• GO:0019588 anaerobic glycerol catabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:1jq5, PDBe:1jq5, PDBj:1jq5
• PDBsum: 1jq5
• PubMed: 11566129
• UniProt: P32816|GLDA_GEOSE Glycerol dehydrogenase (Gene Name=gldA)