Structure of PDB 1jpa Chain A

Receptor sequence
>1jpaA (length=273) Species: 10090 (Mus musculus) [Search protein sequence]
KIFIDPFTFEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLR
EIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVM
IITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRD
LAARNILVNSNLVCKVSDFPIRWTAPEAIQYRKFTSASDVWSYGIVMWEV
MSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNH
RPKFGQIVNTLDKMIRNPNSLKA
3D structure
PDB1jpa Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region.
ChainA
Resolution1.91 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D754 A756 R758 N759 D772 P797
Catalytic site (residue number reindexed from 1) D150 A152 R154 N155 D168 P170
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A A659 F709 M710 L761 A55 F105 M106 L157
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1jpa, PDBe:1jpa, PDBj:1jpa
PDBsum1jpa
PubMed11572780
UniProtP54763|EPHB2_MOUSE Ephrin type-B receptor 2 (Gene Name=Ephb2)

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