Structure of PDB 1jp4 Chain A

Receptor sequence

>1jp4A (length=302) Species: 10116 (Rattus norvegicus)

HNVLMRLVASAYSIAQKAGTIVRCVIAEGDLGIVQKTSATDLQTKADRMV
QMSICSSLSRKFPKLTIIGEEDLPEVDQELIEDGQSEEILKQPCPSQYSA
IKEEDLVVWVDPVDGTKEYTEGLLDNVTVLIGIAYEGKAIAGIINQPYYN
YQAGPDAVLGRTIWGVLGLGAFGFQLKEAPAGKHIITTTRSHSNKLVTDC
IAAMNPDNVLRVGGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVILH
AVGGKLTDIHGNPLQYDKEVKHMNSAGVLAALRNYEYYASRVPESVKSAL
IP

3D structure

• PDB: 1jp4 Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy.
• Chain: A
• Resolution: 1.69 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D51 E74 D117 V119 D120 T122 D247
• Catalytic site (residue number reindexed from 1): D47 E70 D111 V113 D114 T116 D241
• Enzyme Commision number: 3.1.3.57: inositol-1,4-bisphosphate 1-phosphatase.
  3.1.3.7: 3'(2'),5'-bisphosphate nucleotidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PO4	A	E74 D117 V119 D120 G121 T122	E70 D111 V113 D114 G115 T116
BS02	MG	A	D117 D120 D247	D111 D114 D241
BS03	MG	A	E74 D117 V119	E70 D111 V113
BS04	AMP	A	D120 T195 H198 G219 G220 K224 F238 G242 C243 D247	D114 T189 H192 G213 G214 K218 F232 G236 C237 D241

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity
• GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0008150 biological_process
• GO:0046854 phosphatidylinositol phosphate biosynthetic process

External links

• PDB: RCSB:1jp4, PDBe:1jp4, PDBj:1jp4
• PDBsum: 1jp4
• PubMed: 11812139
• UniProt: Q9Z1N4|BPNT1_RAT 3'(2'),5'-bisphosphate nucleotidase 1 (Gene Name=Bpnt1)