Structure of PDB 1jlr Chain A

Receptor sequence
>1jlrA (length=235) Species: 5811 (Toxoplasma gondii) [Search protein sequence]
LLVDPRYSTNDQEESILQDIITRFPNVVLMKQTAQLRAMMTIIRDKETPK
EEFVFYADRLIRLLIEEALNELPFQKKEVTTPLDVSYHGVSFYSKICGVS
IVRAGESMESGLRAVCRGVRIGKILIQRDETTAEPKLIYEKLPADIRERW
VMLLDPMCATAGSVCKAIEVLLRLGVKEERIIFVNILAAPQGIERVFKEY
PKVRMVTAAVDICLNSRYYIVPGIGDFGDRYFGTM
3D structure
PDB1jlr The structural mechanism of GTP stabilized oligomerization and catalytic activation of the Toxoplasma gondii uracil phosphoribosyltransferase.
ChainA
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R137 T141 D235 D238
Catalytic site (residue number reindexed from 1) R128 T132 D226 D229
Enzyme Commision number 2.4.2.9: uracil phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A T169 A170 S172 T160 A161 S163
BS02 GTP A L78 F101 K104 C125 R129 R158 L69 F92 K95 C116 R120 R149 MOAD: Kd=465uM
Gene Ontology
Molecular Function
GO:0004845 uracil phosphoribosyltransferase activity
GO:0005525 GTP binding
GO:0016757 glycosyltransferase activity
Biological Process
GO:0044206 UMP salvage
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:1jlr, PDBe:1jlr, PDBj:1jlr
PDBsum1jlr
PubMed11773618
UniProtQ26998|UPP_TOXGO Uracil phosphoribosyltransferase (Gene Name=uprt)

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