Structure of PDB 1jk2 Chain A

Receptor sequence

>1jk2A (length=85) Species: 10090 (Mus musculus)

RPYACPVESCDRRFSRSAELTRHIRIHTGQKPFQCRICMRNFSRSDHLTT
HIRTHTGEKPFACDICGRKFARSDERKRHTKIHLR

3D structure

• PDB: 1jk2 Rearrangement of side-chains in a Zif268 mutant highlights the complexities of zinc finger-DNA recognition.
• Chain: A
• Resolution: 1.65 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R103 F116 R118 E121 R124 H125 I128 R142 S145 R146 H149 H153 T156 R170 R174 E177 R180	R1 F14 R16 E19 R22 H23 I26 R40 S43 R44 H47 H51 T54 R68 R72 E75 R78	PDBbind-CN: Kd=43pM
BS02	dna	A	D148 S175 K179	D46 S73 K77	PDBbind-CN: Kd=43pM
BS03	ZN	A	C107 C112 H125 H129	C5 C10 H23 H27
BS04	ZN	A	C137 C140 H153 H157	C35 C38 H51 H55
BS05	ZN	A	C165 C168 H181 H185	C63 C66 H79 H83

External links

• PDB: RCSB:1jk2, PDBe:1jk2, PDBj:1jk2
• PDBsum: 1jk2
• PubMed: 11800559
• UniProt: P08046|EGR1_MOUSE Early growth response protein 1 (Gene Name=Egr1)