Structure of PDB 1jij Chain A

Receptor sequence
>1jijA (length=319) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
TNVLIEDLKWRGLIYQQTDEQGIEDLLNKEQVTLYCGADPTADSLHIGHL
LPFLTLRRFQEHGHRPIVLIGGGTGMIGDPSGKSEERVLQTEEQVDKNIE
GISKQMHNIFEFGTDHGAVLVNNRDWLGQISLISFLRDYGKHVGVNYMLG
KDSIQSRLEHGISYTEFTYTILQAIDFGHLNRELNCKIQVGGSDQWGNIT
SGIELMRRMYGQTDAYGLTIPLVTKSDGKKFGKSESGAVWLDAEKTSPYE
FYQFWINQSDEDVIKFLKYFTFLGKEEIDRLEQSKNEAPHLREAQKTLAE
EVTKFIHGEDALNDAIRIS
3D structure
PDB1jij Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors.
ChainA
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) T42 H47 H50 K84 R88 Q174 D195 K231 K234 S235
Catalytic site (residue number reindexed from 1) T41 H46 H49 K83 R87 Q173 D194 K230 K233 S234
Enzyme Commision number 6.1.1.1: tyrosine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 629 A G38 A39 H50 L70 D80 Y170 Q174 D177 G193 D195 Q196 G37 A38 H49 L69 D79 Y169 Q173 D176 G192 D194 Q195 PDBbind-CN: -logKd/Ki=8.52,IC50=3nM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004831 tyrosine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006437 tyrosyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1jij, PDBe:1jij, PDBj:1jij
PDBsum1jij
PubMed11567092
UniProtA6QHR2|SYY_STAAE Tyrosine--tRNA ligase (Gene Name=tyrS)

[Back to BioLiP]