Structure of PDB 1jg1 Chain A

Receptor sequence
>1jg1A (length=215) Species: 2261 (Pyrococcus furiosus) [Search protein sequence]
EKELYEKWMRTVEMLKAEGIIRSKEVERAFLKYPRYLSVEDKYKKYAHID
EPLPIPAGQTVSAPHMVAIMLEIANLKPGMNILEVGTGSGWNAALISEIV
KTDVYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKAPYDVII
VTAGAPKIPEPLIEQLKIGGKLIIPVGSYHLWQELLEVRKTKDGIKIKNH
GGVAFVPLIGEYGWK
3D structure
PDB1jg1 Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate.
ChainA
Resolution1.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S75
Catalytic site (residue number reindexed from 1) S62
Enzyme Commision number 2.1.1.77: protein-L-isoaspartate(D-aspartate) O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A Q72 T73 G99 T100 G101 S102 N105 I120 E121 R122 I123 G147 G149 T165 L221 I222 Q59 T60 G86 T87 G88 S89 N92 I107 E108 R109 I110 G134 G136 T152 L208 I209
Gene Ontology
Molecular Function
GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0016740 transferase activity
Biological Process
GO:0030091 protein repair
GO:0032259 methylation
GO:0036211 protein modification process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:1jg1, PDBe:1jg1, PDBj:1jg1
PDBsum1jg1
PubMed11700066
UniProtQ8TZR3|PIMT_PYRFU Protein-L-isoaspartate O-methyltransferase (Gene Name=pcm)

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