Structure of PDB 1jbw Chain A

Receptor sequence

>1jbwA (length=410) Species: 1582 (Lacticaseibacillus casei)

MNYTETVAYIHSFPRLAKTGDHRRILTLLHALGNPQQQGRYIHVTGTNGK
GSAANAIAHVLEASGLTVGLYTSPFIMRFNERIMIDHEPIPDAALVNAVA
FVRAALERLQQQQADFNVTEFEFITALAYWYFRQRQVDVAVIEVGIGGDT
DSTNVITPVVSVLTEVALDHQKLLGHTITAIAKHKAGIIKRGIPVVTGNL
VPDAAAVVAAKVATTGSQWLRFDRDFSVPKAKLHGWGQRFTYEDQDGRIS
DLEVPLVGDYQQRNMAIAIQTAKVYAKQTEWPLTPQNIRQGLAASHWPAR
LEKISDTPLIVIDGAHNPDGINGLITALKQLFSQPITVIAGILADKDYAA
MADRLTAAFSTVYLVPVPGTRLKDSWQEALAASLNDVPDQPIVITGSLYL
ASAVRQTLLG

3D structure

• PDB: 1jbw Folate-binding triggers the activation of folylpolyglutamate synthetase.
• Chain: A
• Resolution: 1.85 Å

Enzymatic activity

• Enzyme Commision number: 6.3.2.17: tetrahydrofolate synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	S73 E143	S73 E143
BS02	ACQ	A	N48 G49 K50 G51 S52 E143 Y260 N264 R300 D313 A315 H316 S412 L413	N48 G49 K50 G51 S52 E143 Y260 N264 R300 D313 A315 H316 S397 L398
BS03	TMF	A	R15 P74 F75 E120 Y414 S417	R15 P74 F75 E120 Y399 S402

Gene Ontology

Molecular Function

• GO:0004326 tetrahydrofolylpolyglutamate synthase activity
• GO:0005524 ATP binding
• GO:0008841 dihydrofolate synthase activity
• GO:0016874 ligase activity
• GO:0016881 acid-amino acid ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006730 one-carbon metabolic process
• GO:0006761 dihydrofolate biosynthetic process
• GO:0009058 biosynthetic process
• GO:0009396 folic acid-containing compound biosynthetic process
• GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1jbw, PDBe:1jbw, PDBj:1jbw
• PDBsum: 1jbw
• PubMed: 11501996
• UniProt: P15925|FPGS_LACCA Folylpolyglutamate synthase (Gene Name=fpgS)