Structure of PDB 1jbv Chain A

Receptor sequence
>1jbvA (length=404) Species: 1582 (Lacticaseibacillus casei) [Search protein sequence]
MNYTETVAYIHSFPGDHRRILTLLHALGNPQQQGRYIHVTGTNGKGSAAN
AIAHVLEASGLTVGLYTSPFIMRFNERIMIDHEPIPDAALVNAVAFVRAA
LERLQQQQADFNVTEFEFITALAYWYFRQRQVDVAVIEVGIGGDTDSTNV
ITPVVSVLTEVALDHQKLLGHTITAIAKHKAGIIKRGIPVVTGNLVPDAA
AVVAAKVATTGSQWLRFDRDFSVPKAKLHGWGQRFTYEDQDGRISDLEVP
LVGDYQQRNMAIAIQTAKVYAKQTEWPLTPQNIRQGLAASHWPARLEKIS
DTPLIVIDGAHNPDGINGLITALKQLFSQPITVIAGAMADRLTAAFSTVY
LVPVPGTPRALPEARLKDSWQEALAASLNDVPDQPIVITGSLYLASAVRQ
TLLG
3D structure
PDB1jbv Folate-binding triggers the activation of folylpolyglutamate synthetase.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.17: tetrahydrofolate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S73 E143 S68 E138
BS02 ACP A N48 G49 K50 G51 S52 E143 A299 R300 G314 L413 N43 G44 K45 G46 S47 E138 A294 R295 G309 L392
Gene Ontology
Molecular Function
GO:0004326 tetrahydrofolylpolyglutamate synthase activity
GO:0005524 ATP binding
GO:0008841 dihydrofolate synthase activity
GO:0016874 ligase activity
GO:0016881 acid-amino acid ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0006761 dihydrofolate biosynthetic process
GO:0009058 biosynthetic process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1jbv, PDBe:1jbv, PDBj:1jbv
PDBsum1jbv
PubMed11501996
UniProtP15925|FPGS_LACCA Folylpolyglutamate synthase (Gene Name=fpgS)

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