Structure of PDB 1j8f Chain A

Receptor sequence
>1j8fA (length=312) Species: 9606 (Homo sapiens) [Search protein sequence]
GEADMDFLRNLFRLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIP
DFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFK
PTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSH
CVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFF
SCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSD
PFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDL
VRREHASIDAQS
3D structure
PDB1j8f Structure of the histone deacetylase SIRT2.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P94 D95 F96 R97 N168 D170 H187
Catalytic site (residue number reindexed from 1) P50 D51 F52 R53 N124 D126 H143
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C195 C200 C221 C224 C151 C156 C177 C180
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:1j8f, PDBe:1j8f, PDBj:1j8f
PDBsum1j8f
PubMed11427894
UniProtQ8IXJ6|SIR2_HUMAN NAD-dependent protein deacetylase sirtuin-2 (Gene Name=SIRT2)

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