Structure of PDB 1j1w Chain A

Receptor sequence
>1j1wA (length=738) Species: 354 (Azotobacter vinelandii) [Search protein sequence]
TPKIIYTLTDEAPALATYSLLPIIKAFTGSSGIAVETRDISLAGRLIATF
PEYLTDTQKISDDLAELGKLATTPDANIIKLPNISASVPQLKAAIKELQQ
QGYKLPDYPEEPKTDTEKDVKARYDKIKGSAVNPVLREGNSDRRAPLSVK
NYARKHPHKMGAWSADSKSHVAHMDNGDFYGSEKAALIGAPGSVKIELIA
KDGSSTVLKAKTSVQAGEIIDSSVMSKNALRNFIAAEIEDAKKQGVLLSV
HLKATMMKVSDPIMFGQIVSEFYKDALTKHAEVLKQIGFDVNNGIGDLYA
RIKTLPEAKQKEIEADIQAVYAQRPQLAMVNSDKGITNLHVPSDVIVDAS
MPAMIRDSGKMWGPDGKLHDTKAVIPDRCYAGVYQVVIEDCKQHGAFDPT
TMGSVPNVGLMAQKAEEYGSHDKTFQIPADGVVRVTDESGKLLLEQSVEA
GDIWRMCQAKDAPIQDWVKLAVNRARATNTPAVFWLDPARAHDAQVIAKV
ERYLKDYDTSGLDIRILSPVEATRFSLARIREGKDTISVTGNVLRDYLTD
LFPIMELGTSAKMLSIVPLMSGGGLFETGAGGSAPKHVQQFLEEGYLRWD
SLGEFLALAASLEHLGNAYKNPKALVLASTLDQATGKILDNNKSPARKVG
EIDNRGSHFYLALYWAQALAAQTEDKELQAQFTGIAKALTDNETKIVGEL
AAAQGKPVDIAGYYHPNTDLTSKAMRPSATFNAALAPL
3D structure
PDB1j1w Crystal Structure of the Monomeric Isocitrate Dehydrogenase in the Presence of NADP+
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.42: isocitrate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A P84 N85 S87 N135 T561 A563 G583 G584 S585 H589 R600 W601 D602 R649 P82 N83 S85 N133 T559 A561 G581 G582 S583 H587 R598 W599 D600 R647
Gene Ontology
Molecular Function
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:1j1w, PDBe:1j1w, PDBj:1j1w
PDBsum1j1w
PubMed12855708
UniProtP16100|IDH_AZOVI Isocitrate dehydrogenase [NADP] (Gene Name=icd)

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